AGS3 Polyclonal Antibody

  • Catalog No.:YT0143
  • Applications:IHC-p,IF(paraffin section),ELISA
  • Reactivity:Human,Mouse,Rat
    • Gene Name:
    • GPSM1
    • Protein Name:
    • G-protein-signaling modulator 1
    • Human Swiss Prot No:
    • Q86YR5
    • Mouse Swiss Prot No:
    • Q6IR34
    • Immunogen:
    • Synthesized peptide derived from the Internal region of human AGS3.
    • Specificity:
    • AGS3 Polyclonal Antibody detects endogenous levels of AGS3 protein.
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Polyclonal Rabbit
    • Dilution:
    • Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
    • Purification:
    • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Other Name:
    • GPSM1; AGS3; G-protein-signaling modulator 1; Activator of G-protein signaling 3
    • MolecularWeight(Da):
    • 72136
    • Background:
    • G-protein signaling modulator 1(GPSM1) Homo sapiens G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
    • Function:
    • domain:The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.,function:Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.,PTM:Phosphorylation regulates interaction with G(i/o) alpha.,similarity:Belongs to the GPSM family.,similarity:Contains 4 GoLoco domains.,similarity:Contains 9 TPR repeats.,subunit:Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact
    • Subcellular Location:
    • Golgi membrane,endoplasmic reticulum membrane,cytosol,plasma membrane,
    • Expression:
    • Brain,Fetal brain,Mammary cancer,Rhabdomyosarcoma,