• Target：
• AGS3

• Fields：
• >>Cocaine addiction

• Gene Name：
• GPSM1

• Protein Name：
• G-protein-signaling modulator 1

• Human Gene Id：
• 26086

• Human Swiss Prot No：
• Q86YR5

• Mouse Gene Id：
• 67839

• Mouse Swiss Prot No：
• Q6IR34

• Rat Gene Id：
• 246254

• Rat Swiss Prot No：
• Q9R080

• Immunogen：
• Synthesized peptide derived from the Internal region of human AGS3.

• Specificity：
• AGS3 Polyclonal Antibody detects endogenous levels of AGS3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GPSM1;AGS3;G-protein-signaling modulator 1;Activator of G-protein signaling 3

• Molecular Weight(Da)：
• 72kD

• Background：
• G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],

• Function：
• domain:The GoLoco domains mediate interaction with G(i/o) alpha (By similarity). The GoLoco domains are essential for the GDI activity toward G(i/o) alpha.,function:Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction.,PTM:Phosphorylation regulates interaction with G(i/o) alpha.,similarity:Belongs to the GPSM family.,similarity:Contains 4 GoLoco domains.,similarity:Contains 9 TPR repeats.,subunit:Interacts with GNAI1, GNAI2 and GNAI3 preferentially in their GDP-bound state. May also interact

• Subcellular Location：
• Cytoplasm, cytosol. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

• Expression：
• Expressed in intestinal cells.

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