FoxO4 (Phospho Ser193) rabbit pAb

  • Catalog No.：YP1343
  • Applications：WB
  • Reactivity：Human;Rat;Mouse;
    • Target：
    • FoxO4
    • Fields：
    • >>Ras signaling pathway;>>FoxO signaling pathway;>>Shigellosis
    • Gene Name：
    • FOXO4 AFX AFX1 MLLT7
    • Protein Name：
    • FoxO4 (Ser193)
    • Human Gene Id：
    • 4303
    • Human Swiss Prot No：
    • P98177
    • Mouse Swiss Prot No：
    • Q9WVH3
    • Immunogen：
    • Synthesized phosho peptide around human FoxO4 (Ser193)
    • Specificity：
    • This antibody detects endogenous levels of Human FoxO4 (phospho-Ser193)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Forkhead box protein O4 (Fork head domain transcription factor AFX1)
    • Observed Band(KD)：
    • 55kD
    • Background：
    • This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010],
    • Function：
    • disease:A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with MLL/HRX. The result is a rogue activator protein.,function:Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.,pharmaceutical:A constitutively active FOXO4 mutant where phosphorylation sites Thr-32, Ser-187 and Ser-262 have been mutated to alanine may have therapeutic potential in ERBB2/HER2-overexpressing cancers as it inhibits ERBB2-mediated cell survival, transformation and tumorigenicity.,PTM:Acetylation by CBP, which is induced by peroxidase stress, inhibits transcriptional activity. Dea
    • Subcellular Location：
    • Cytoplasm. Nucleus. When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
    • Expression：
    • Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.

    Attributes

    • Code：
    • YP1343
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-04-28
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