• Target：
• Tyro3

• Gene Name：
• TYRO3

• Protein Name：
• Tyrosine-protein kinase receptor TYRO3

• Human Gene Id：
• 7301

• Human Swiss Prot No：
• Q06418

• Mouse Swiss Prot No：
• P55144

• Immunogen：
• Purified recombinant fragment of Tyro3 expressed in E. Coli.

• Specificity：
• Tyro3 Monoclonal Antibody detects endogenous levels of Tyro3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TYRO3;BYK;DTK;RSE;SKY;Tyrosine-protein kinase receptor TYRO3;Tyrosine-protein kinase DTK;Tyrosine-protein kinase RSE;Tyrosine-protein kinase SKY;Tyrosine-protein kinase byk

• Molecular Weight(Da)：
• 97kD

• References：
• 1. Janssen, J.W.G., et al. 1991. Oncogene 6: 2113-2120.
  2. Schlessinger, J., et al. 1992. Neuron 9: 383-391.
  3. Biesecker, L.G., et al. 1995. Oncogene 10: 2239-2242.

• Background：
• The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:May be involved in cell adhesion processes, particularly in the central nervous system. In case of filovirus infection, seems to function as a cell entry factor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Monomer and homodimer. Interacts with GAS6.,tissue specificity:Abundant in the brain and lower levels in other tissues.,

• Subcellular Location：
• Cell membrane; Single-pass type I membrane protein.

• Expression：
• Abundant in the brain and lower levels in other tissues.

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