• Target：
• KLHL13

• Fields：
• >>Ubiquitin mediated proteolysis

• Gene Name：
• KLHL13

• Protein Name：
• Kelch-like protein 13

• Human Gene Id：
• 90293

• Human Swiss Prot No：
• Q9P2N7

• Mouse Swiss Prot No：
• Q80TF4

• Immunogen：
• Purified recombinant fragment of human KLHL13 expressed in E. Coli.

• Specificity：
• KLHL13 Monoclonal Antibody detects endogenous levels of KLHL13 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• KLHL13;BKLHD2;KIAA1309;Kelch-like protein 13;BTB and kelch domain-containing protein 2

• Molecular Weight(Da)：
• 74kD

• References：
• 1. DNA Res. 2000 Feb 28;7(1):65-73.
  2. Genome Res. 2004 Sep;14(9):1711-8.
  3. Cell. 2009 Jul 23;138(2):389-403.

• Background：
• This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and other proteins to form the Cullin 3-based E3 ubiquitin-protein ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],

• Function：
• function:Substrate-specific adapter for a CUL3-based E3 ubiquitin-protein ligase complex. Within this complex, controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 BACK (BTB/Kelch associated) domain.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Forms a complex with CUL3 and KLHL9. Interacts with AURKB. Interacts with CUL3.,

• Subcellular Location：
• midbody,Cul3-RING ubiquitin ligase complex,

• Expression：
• Brain,Testis,Thalamus,Whole embryo,

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