• Target：
• GATA-3

• Fields：
• >>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Parathyroid hormone synthesis, secretion and action;>>Inflammatory bowel disease

• Gene Name：
• GATA3

• Protein Name：
• Trans-acting T-cell-specific transcription factor GATA-3

• Human Gene Id：
• 2624

• Human Swiss Prot No：
• P23771

• Mouse Swiss Prot No：
• P23772

• Immunogen：
• Purified recombinant fragment of human GATA-3 expressed in E. Coli.

• Specificity：
• GATA-3 Monoclonal Antibody detects endogenous levels of GATA-3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GATA3;Trans-acting T-cell-specific transcription factor GATA-3;GATA-binding factor 3

• Molecular Weight(Da)：
• 48kD

• References：
• 1. Biogerontology. 2009 Oct;10(5):593-604.
  2. Arthritis Rheum. 2009 Mar;60(3):750-9.

• Background：
• This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009],

• Function：
• disease:Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also known as Barakat syndrome.,function:Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'.,similarity:Contains 2 GATA-type zinc fingers.,tissue specificity:T-cells and endothelial cells.,

• Subcellular Location：
• Nucleus.

• Expression：
• T-cells and endothelial cells.

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