• Target：
• Crk-L

• Fields：
• >>MAPK signaling pathway;>>ErbB signaling pathway;>>Rap1 signaling pathway;>>Chemokine signaling pathway;>>Focal adhesion;>>Fc gamma R-mediated phagocytosis;>>Neurotrophin signaling pathway;>>Regulation of actin cytoskeleton;>>Insulin signaling pathway;>>Growth hormone synthesis, secretion and action;>>Bacterial invasion of epithelial cells;>>Shigellosis;>>Yersinia infection;>>Human cytomegalovirus infection;>>Human immunodeficiency virus 1 infection;>>Pathways in cancer;>>MicroRNAs in cancer;>>Renal cell carcinoma;>>Chronic myeloid leukemia

• Gene Name：
• CRKL

• Protein Name：
• Crk-like protein

• Human Gene Id：
• 1399

• Human Swiss Prot No：
• P46109

• Mouse Swiss Prot No：
• P47941

• Immunogen：
• Purified recombinant fragment of human Crk-L expressed in E. Coli.

• Specificity：
• Crk-L Monoclonal Antibody detects endogenous levels of Crk-L protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CRKL;Crk-like protein

• Molecular Weight(Da)：
• 34kD

• References：
• 1. Mol Cell Biol. 2009 Jun;29(11):3076-87.
  2. Cell. 2009 Jul 23;138(2):389-403.

• Background：
• This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009],

• Function：
• function:May mediate the transduction of intracellular signals.,similarity:Contains 1 SH2 domain.,similarity:Contains 2 SH3 domains.,subunit:Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.,

• Subcellular Location：
• endosome,cytosol,cell-cell adherens junction,extracellular exosome,

• Expression：
• Skin,Spleen,

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