• Target：
• BLK

• Gene Name：
• BLK

• Protein Name：
• Tyrosine-protein kinase Blk

• Human Gene Id：
• 640

• Human Swiss Prot No：
• P51451

• Mouse Swiss Prot No：
• P16277

• Immunogen：
• Purified recombinant fragment of human Blk expressed in E. Coli.

• Specificity：
• Blk Monoclonal Antibody detects endogenous levels of Blk protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• BLK;Tyrosine-protein kinase Blk;B lymphocyte kinase;p55-Blk

• Molecular Weight(Da)：
• 58kD

• References：
• 1. N Engl J Med. 2008 Feb 28;358(9):900-9.
  2. Genes Immun. 2009 Apr;10(3):219-26.
  3. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14460-5.

• Background：
• This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:May function in a signal transduction pathway that is restricted to B-lymphoid cells.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,

• Subcellular Location：
• Cell membrane ; Lipid-anchor . Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). .

• Expression：
• Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.

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