• Target：
• Axl

• Fields：
• >>EGFR tyrosine kinase inhibitor resistance

• Gene Name：
• AXL UFO

• Protein Name：
• Tyrosine-protein kinase receptor UFO

• Human Gene Id：
• 558

• Human Swiss Prot No：
• P30530

• Mouse Swiss Prot No：
• Q00993

• Immunogen：
• Purified recombinant extracellular fragment of human Axl fused with hIgGFc tag expressed in HEK293 cell line.

• Specificity：
• Axl Monoclonal Antibody detects endogenous levels of Axl protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• AXL;UFO;Tyrosine-protein kinase receptor UFO;AXL oncogene

• Observed Band(KD)：
• 130kD

• References：
• 1. Br J Cancer. 2006 May 22;94(10):1446-51.
  2. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5799-804.

• Background：
• The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia.,function:May function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, seems to function as a cell entry factor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Heterodimer and heterotetramer with GAS6.,tissue specificity:Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.,

• Subcellular Location：
• Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.

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