TIGIT (PN0530) Nb-FC recombinant antibody

  • Catalog No.：YA0645
  • Applications：ELISA
  • Reactivity：Human
    • Target：
    • TIGIT
    • Gene Name：
    • TIGIT VSIG9 VSTM3
    • Protein Name：
    • T-cell immunoreceptor with Ig and ITIM domains (V-set and immunoglobulin domain-containing protein 9) (V-set and transmembrane domain-containing protein 3)
    • Human Swiss Prot No：
    • Q495A1
    • Immunogen：
    • Purified recombinant Human TIGIT
    • Specificity：
    • This recombinant monoclonal antibody can detects endogenous levels of TIGIT protein.
    • Formulation：
    • Phosphate-buffered solution
    • Source：
    • Camel, chimeric fusion of Nanobody (VHH) and mouse IgG1 Fc domain , recombinantly produced from 293F cell
    • Dilution：
    • ELISA 1:5000-100000
    • Purification：
    • Recombinant Expression and Affinity purified
    • Concentration：
    • Please check the information on the tube
    • Storage Stability：
    • -15°C to -25°C/1 year(Avoid freeze / thaw cycles)
    • Other Name：
    • T-cell immunoreceptor with Ig and ITIM domains;VSIG9;VSTM3;WUCAM;TIGIT nanobody;
    • Background：
    • T cell immunoreceptor with Ig and ITIM domains (TIGIT), also known as VSTM3 or WUCAM, is a 26 kD, type I transmembrane protein and is a member of the PVR (poliovirus receptor) family of immunoglobulin-like domain containing proteins. TIGIT is expressed on activated T cells, follicular T helper, memory, and regulatory T cells as well as on NK cells. TIGIT is a negative regulator of NK and T cell activation. Expression of TIGIT is associated with decreased functionality of CD8 T cells in chronic viral infection and tumors. TIGIT also promotes the differentiation of tolerogenic phenotype in dendritic cells with an increased secretion of IL-10 and a diminished production of IL-12.
    • Function：
    • Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.
    • Subcellular Location：
    • Cell membrane ; Single-pass type I membrane protein .
    • Expression：
    • Expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level).

    Attributes

    • Code：
    • YA0645
    • Size
    • 40μg / 100μg / 200μg
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-06-28
    Order

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