Cleaved-Caspase-7 p20 (D198) Cell-Based Colorimetric ELISA Kit

  • Catalog No.：KA3923C
  • Applications：ELISA
  • Reactivity：Human;Mouse
    • Gene Name：
    • CASP7
    • Protein Name：
    • Caspase7
    • Human Gene Id：
    • 840
    • Human Swiss Prot No：
    • P55210
    • Mouse Swiss Prot No：
    • P97864
    • Storage Stability：
    • 2-8°C/6 months
    • Other Name：
    • Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20;Caspase-7 subunit p11]
    • Detection Method：
    • Colorimetric
    • Background：
    • catalytic activity:Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val-Asp-|-.,enzyme regulation:Inhibited by isatin sulfonamides.,function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Overexpression promotes programmed cell death.,PTM:Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur.,similarity:Belongs to the peptidase C14A family.,subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit.,tissue specificity:Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.,
    • Function：
    • release of cytochrome c from mitochondria, proteolysis, apoptosis, mitochondrion organization, heart development,cell death, apoptotic mitochondrial changes, response to radiation, response to UV, response to light stimulus,response to abiotic stimulus, programmed cell death, death,
    • Subcellular Location：
    • Cytoplasm.
    • Expression：
    • Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.

    Attributes

    • Code：
    • KA3923C
    • Size
    • 96 / well
    • Price$：
    • 330
    • Delivery：
    • 2024-05-10
    Order

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