Total Dyrk1A Cell-Based Colorimetric ELISA Kit

  • Catalog No.:KA3723C
  • Applications:ELISA
  • Reactivity:Human;Mouse;Rat
    • Gene Name:
    • DYRK1A
    • Human Gene Id:
    • 1859
    • Human Swiss Prot No:
    • Q13627
    • Mouse Swiss Prot No:
    • Q61214
    • Storage Stability:
    • 2-8°C/6 months
    • Other Name:
    • Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
    • Detection Method:
    • Colorimetric
    • Background:
    • alternative products:Additional isoforms seem to exist,catalytic activity:ATP + a protein = ADP + a phosphoprotein.,developmental stage:Expressed in the developing central nervous system.,disease:Overexpressed 1.5-fold in fetal Down syndrome brain.,enzyme regulation:Inhibited by RANBP9.,function:May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.,PTM:Autophosphorylated on tyrosine residues.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts RAD54L2/ARIP4 (By similarity). Interacts with RANBP9.,tissue specificity:Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.,
    • Function:
    • protein amino acid phosphorylation, phosphorus metabolic process, phosphate metabolic process, phosphorylation,peptidyl-tyrosine phosphorylation, peptidyl-tyrosine modification, protein amino acid autophosphorylation,
    • Subcellular Location:
    • Nucleus . Nucleus speckle .
    • Expression:
    • Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.