AP-1 Monoclonal Antibody

    • Catalog No.:YM1010
    • Applications:WB
    • Reactivity:Human
      • Gene Name:
      • JUN
      • Protein Name:
      • Transcription factor AP-1
      • Human Gene Id:
      • 3725
      • Human Swiss Prot No:
      • P05412
      • Mouse Swiss Prot No:
      • P05627
      • Immunogen:
      • Purified recombinant human AP-1 protein fragments expressed in E.coli.
      • Specificity:
      • AP-1 Monoclonal Antibody detects endogenous levels of AP-1 protein.
      • Formulation:
      • Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50% glycerol.
      • Source:
      • Mouse
      • Dilution:
      • Western Blot: 1/1000 - 1/2000. Not yet tested in other applications.
      • Purification:
      • Affinity purification
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -20°C/1 year
      • Other Name:
      • JUN; Transcription factor AP-1; Activator protein 1; AP1; Proto-oncogene c-Jun; V-jun avian sarcoma virus 17 oncogene homolog; p39
      • Observed Band(KD):
      • 39-42
      • Background:
      • Jun proto-oncogene, AP-1 transcription factor subunit(JUN) Homo sapiens This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008],
      • Function:
      • function:Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.,PTM:Phosphorylation enhances the transcriptional activity. Phosphorylated by PRKDC.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. Jun subfamily.,similarity:Contains 1 bZIP domain.,subunit:Heterodimer with either FOS or BATF3. Interacts with HIVEP3 (By similarity). Interacts with SMAD3/SMAD4 heterodimers. Interacts with MYBBP1A, SPIB and TCF20. Interacts with COPS5; indirectly leading to its phosphorylation. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.,
      • Subcellular Location:
      • nuclear chromosome,nucleus,nucleoplasm,transcription factor complex,nuclear euchromatin,cytosol,transcriptional repressor complex,
      • Expression:
      • B-cell,Epithelium,Ovary,Testis,Uterus,
      • Products Images
      • Western Blot analysis using AP-1 Monoclonal Antibody against 293, 3T3 cell lysate.