• Gene Name：
• ACTB

• Protein Name：
• Actin cytoplasmic 1

• Human Gene Id：
• 60

• Human Swiss Prot No：
• P60709

• Immunogen：
• Synthetic Peptide of β-actin

• Specificity：
• This monoclonal Hybridoma can product antibody detects Actin cytoplasmic 1 protein. Please see the antibody (catalog# YM3133) for more information in our website

• Source：
• Mouse

• Dilution：
• WB 1:500-10000

• Storage Stability：
• liquid nitrogen

• Other Name：
• ACTB; Actin, cytoplasmic 1; Beta-actin

• Background：
• disease:Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYTJ patients manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.,function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.,similarity:Belongs to the actin family.,subunit:Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Interacts with XPO6.,

• Function：
• cell morphogenesis, cell morphogenesis involved in differentiation, cell motion, axonogenesis, response to inorganic substance, response to metal ion, cell projection organization, neuron differentiation, neuron projection development,cellular component morphogenesis, cell part morphogenesis, neuron development, cell morphogenesis involved in neuron differentiation, neuron projection morphogenesis, cell projection morphogenesis, response to calcium ion,

• Subcellular Location：
• Cytoplasm, cytoskeleton . Nucleus . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .

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