Catalog: YM8101
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
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Collected
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Main Information
Target
KLF4
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
55kD (Calculated)
60kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1000; WB 1:1000-5000; IF 1:200-1000; ELISA 1:5000-20000;
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
55kD
MW(Observed)
60kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0167R
Isotype
IgG,Kappa
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RS0002
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Primary Antibodies
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Primary Antibodies
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Antigen&Target Information
Specificity:
Endogenous
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Gene Name:
KLF4
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Protein Name:
Krueppel-like factor 4
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Other Name:
KLF4 ;
EZF ;
GKLF ;
Krueppel-like factor 4 ;
Epithelial zinc finger protein EZF ;
Gut-enriched krueppel-like factor
EZF ;
GKLF ;
Krueppel-like factor 4 ;
Epithelial zinc finger protein EZF ;
Gut-enriched krueppel-like factor
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Background:
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015],
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Function:
Function:Transcription factor which acts as both an activator and repressor. Binds the CACCC core sequence. Binds to multiple sites in the 5'-flanking region of its own gene and can activate its own transcription. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 3 C2H2-type zinc fingers.,subunit:Interaction with the C-terminal domain of MUC1 enhances suppression of TP53/p53 transcription.,
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Cellular Localization:
Nuclear
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Tissue Expression:
Research Areas:
>>Signaling pathways regulating pluripotency of stem cells ;
>>Chemical carcinogenesis - receptor activation
>>Chemical carcinogenesis - receptor activation
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM8101
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
Collect
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