Catalog: YN0812
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$150.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
KI2L2
Host Species
Rabbit
Reactivity
Human
Applications
WB, ELISA
MW
38kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
KI2L2 Polyclonal Antibody detects endogenous levels of protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
38kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from part region of human protein. AA range:49-149
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Specificity:
KI2L2 Polyclonal Antibody detects endogenous levels of protein.
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Gene Name:
KIR2DL2 CD158B1 NKAT6
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Protein Name:
Killer cell immunoglobulin-like receptor 2DL2 (CD158 antigen-like family member B1) (MHC class I NK cell receptor) (Natural killer-associated transcript 6) (NKAT-6) (p58 natural killer cell receptor clone CL-43) (p58 NK receptor CL-43) (CD antigen CD158b1)
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Background:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC) . The gene content of the KIR gene cluster varies among haplotypes , although several "framework" genes are found in all haplotypes (KIR3DL3 , KIR3DP1 , KIR3DL4 , KIR3DL2) . The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM) , while KIR proteins with the short cytoplasmic domain lack the
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Function:
Function:Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. ,miscellaneous:PubMed:15580659 , identified a chromosomal rearrangement producing a recombinant gene composed of the promoter and first exon of KIR2DL5A fused to KIR3DP1 which was originally thought to be a pseudogene. This leads to the expression in 4.5 percent of a Spanish Caucasoid population of an mRNA which may encode a chimeric protein KIR2DL5A/KIR3DP1. ,similarity:Belongs to the immunoglobulin superfamily. ,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains. ,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains. ,tissue specificity:Expressed in peripheral blood cells. ,
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Cellular Localization:
Cell membrane; Single-pass type I membrane protein.
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Tissue Expression:
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Research Areas:
>>Antigen processing and presentation ;
>>Natural killer cell mediated cytotoxicity ;
>>Graft-versus-host disease
>>Natural killer cell mediated cytotoxicity ;
>>Graft-versus-host disease
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YN0812
Size
Price
Status
Qty.
200μL
$450.00
3 weeks
0
100μL
$280.00
3 weeks
0
40μL
$150.00
3 weeks
0
Add to cart
Collected
Collect
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