Endogenous

MAP2K3

Dual specificity mitogen-activated protein kinase kinase 3

MAP2K3 ;
MEK3 ;
MKK3 ;
PRKMK3 ;
SKK2 ;
Dual specificity mitogen-activated protein kinase kinase 3 ;
MAP kinase kinase 3 ;
MAPKK 3 ;
MAPK/ERK kinase 3 ;
MEK 3 ;
Stress-activated protein kinase kinase 2 ;
SAPK kinase 2 ;
SAPKK-2 ;
SAPKK2

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in MAP2K3 may be involved in colon cancer.,enzyme regulation:Activated by dual phosphorylation on Ser-218 and Thr-222.,Function:Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.,PTM:Autophosphorylated.,PTM:Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases regulates positively the kinase activity.,PTM:Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds to DYRK1B/MIRK and increases its kinase activity. Part of a complex with MAP3K3, RAC1 and CCM2. Interacts with Yersinia yopJ.,tissue specificity:Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.,

Cytoplasm, Nucleus

>>Autophagy - animal ;
>>mTOR signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Thermogenesis ;
>>Shigellosis