Catalog: YT2327
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
IL-21
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
18kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
IL-21 Polyclonal Antibody detects endogenous levels of IL-21 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
18kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human IL21. AA range:91-140
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Specificity:
IL-21 Polyclonal Antibody detects endogenous levels of IL-21 protein.
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Gene Name:
IL21
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Protein Name:
Interleukin-21
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Other Name:
IL21 ;
Interleukin-21 ;
IL-21 ;
Za11
Interleukin-21 ;
IL-21 ;
Za11
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Background:
This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],
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Function:
Function:Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.,similarity:Belongs to the IL-15/IL-21 family.,tissue specificity:Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes.,
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Cellular Localization:
Secreted .
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Tissue Expression:
Research Areas:
>>Cytokine-cytokine receptor interaction ;
>>JAK-STAT signaling pathway ;
>>Th17 cell differentiation ;
>>Inflammatory bowel disease
>>JAK-STAT signaling pathway ;
>>Th17 cell differentiation ;
>>Inflammatory bowel disease
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Signaling Pathway
Organismal Systems >> Immune system >> Th17 cell differentiation
Human Diseases >> Immune disease >> Inflammatory bowel disease
Environmental Information Processing >> Signal transduction >> JAK-STAT signaling pathway
Environmental Information Processing >> Signaling molecules and interaction >> Cytokine-cytokine receptor interaction
Reference Citation({{totalcount}})
Catalog: YT2327
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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