Catalog: YT4408
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
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Main Information
Target
SR-6
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
47kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
SR-6 Polyclonal Antibody detects endogenous levels of SR-6 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
47kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human 5-HT-6. AA range:221-270
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Specificity:
SR-6 Polyclonal Antibody detects endogenous levels of SR-6 protein.
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Gene Name:
HTR6
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Protein Name:
5-hydroxytryptamine receptor 6
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Other Name:
HTR6 ;
5-hydroxytryptamine receptor 6 ;
5-HT-6 ;
5-HT6 ;
Serotonin receptor 6
5-hydroxytryptamine receptor 6 ;
5-HT-6 ;
5-HT6 ;
Serotonin receptor 6
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Database Link:
Background:
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013],
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Function:
Function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expressed in several human brain regions, most prominently in the caudate nucleus.,
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Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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Tissue Expression:
Research Areas:
>>Calcium signaling pathway ;
>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Serotonergic synapse
>>cAMP signaling pathway ;
>>Neuroactive ligand-receptor interaction ;
>>Serotonergic synapse
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT4408
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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