Catalog: YT2968
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
Na+ CP type VIIα
Host Species
Rabbit
Reactivity
Human, Monkey
Applications
WB, IHC, IF
MW
200kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000;
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Na+ CP type VIIα Polyclonal Antibody detects endogenous levels of Na+ CP type VIIα protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
200kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human SCN7A. AA range:771-820
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Specificity:
Na+ CP type VIIα Polyclonal Antibody detects endogenous levels of Na+ CP type VIIα protein.
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Gene Name:
SCN7A
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Protein Name:
Sodium channel protein type 7 subunit alpha
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Other Name:
SCN7A ;
SCN6A ;
Sodium channel protein type 7 subunit alpha ;
Putative voltage-gated sodium channel subunit alpha Nax ;
Sodium channel protein cardiac and skeletal muscle subunit alpha ;
Sodium channel protein type VII subunit alpha
SCN6A ;
Sodium channel protein type 7 subunit alpha ;
Putative voltage-gated sodium channel subunit alpha Nax ;
Sodium channel protein cardiac and skeletal muscle subunit alpha ;
Sodium channel protein type VII subunit alpha
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Background:
This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown. [provided by RefSeq, Dec 2011],
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Function:
Domain:The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.,Function:Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.,similarity:Belongs to the sodium channel family.,tissue specificity:Heart and uterus.,
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Cellular Localization:
Cell membrane ; Multi-pass membrane protein .
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Tissue Expression:
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Research Areas:
>>Adrenergic signaling in cardiomyocytes
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT2968
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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