Catalog: YT2318
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
IL-17Rα
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
90kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:40000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
IL-17Rα Polyclonal Antibody detects endogenous levels of IL-17Rα protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
90kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human IL17RA. AA range:141-190
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Specificity:
IL-17Rα Polyclonal Antibody detects endogenous levels of IL-17Rα protein.
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Gene Name:
IL17RA
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Protein Name:
Interleukin-17 receptor A
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Other Name:
IL17RA ;
IL17R ;
Interleukin-17 receptor A ;
IL-17 receptor A ;
IL-17RA ;
CDw217 ;
CD antigen CD217
IL17R ;
Interleukin-17 receptor A ;
IL-17 receptor A ;
IL-17RA ;
CDw217 ;
CD antigen CD217
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Background:
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014],
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Function:
Function:Receptor for IL17A. Binds its ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling.,PTM:Glycosylated.,tissue specificity:Widely expressed.,
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Cellular Localization:
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
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Tissue Expression:
Widely expressed.
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Research Areas:
>>Cytokine-cytokine receptor interaction ;
>>IL-17 signaling pathway ;
>>Alcoholic liver disease
>>IL-17 signaling pathway ;
>>Alcoholic liver disease
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT2318
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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