Catalog: YN3291
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
GRIK4
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB
MW
105kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of DSE at Human/Mouse
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
105kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human DSE AA range: 164-214
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Specificity:
This antibody detects endogenous levels of DSE at Human/Mouse
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Gene Name:
DSE SART2
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Protein Name:
DSE
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Other Name:
Dermatan-sulfate epimerase ;
DS epimerase ;
Chondroitin-glucuronate 5-epimerase ;
Squamous cell carcinoma antigen recognized by T-cells 2 ;
SART-2 ;
DS epimerase ;
Chondroitin-glucuronate 5-epimerase ;
Squamous cell carcinoma antigen recognized by T-cells 2 ;
SART-2 ;
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Background:
The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016],
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Function:
Catalytic activity:Chondroitin D-glucuronate = dermatan L-iduronate.,Function:Converts D-glucuronic acid to L-iduronic acid (IdoUA) residues.,pathway:Glycan metabolism; chondroitin sulfate biosynthesis.,pathway:Glycan metabolism; heparan sulfate biosynthesis.,similarity:Belongs to the dermatan-sulfate isomerase family.,tissue specificity:Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level).,
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Cellular Localization:
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Microsome membrane ; Multi-pass membrane protein .
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Tissue Expression:
Ubiquitously expressed with higher expression in kidney and ovary and lower expression in brain, colon and thymus. Also expressed in renal cell carcinomas, brain tumors, and in a part of melanomas and adenocarcinomas from organs other than the breast. Expressed in squamous cell carcinomas (SCC), glioma, and some adenocarcinoma cell lines, but not in breast cancer cell lines or any normal tissues (at protein level).
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Research Areas:
>>Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate ;
>>Metabolic pathways
>>Metabolic pathways
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Reference Citation({{totalcount}})
Catalog: YN3291
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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