Catalog: YM0089
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
Calnexin
Host Species
Mouse
Reactivity
Human
Applications
WB, IF, ELISA
MW
68kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Calnexin Monoclonal Antibody detects endogenous levels of Calnexin protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
68kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
10E1
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Antigen&Target Information
Immunogen:
Synthetic peptide corresponding to aa (CEAAEERPWLWVVYILTVAL) of human Calnexin, conjugated to KLH.
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Specificity:
Calnexin Monoclonal Antibody detects endogenous levels of Calnexin protein.
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Gene Name:
CANX
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Protein Name:
Calnexin
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Other Name:
CANX ;
Calnexin ;
IP90 ;
Major histocompatibility complex class I antigen-binding protein p88 ;
p90
Calnexin ;
IP90 ;
Major histocompatibility complex class I antigen-binding protein p88 ;
p90
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Background:
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008],
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Function:
Function:Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.,online information:Calnexin entry,similarity:Belongs to the calreticulin family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,
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Cellular Localization:
Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Endoplasmic reticulum . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232). .
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Tissue Expression:
B-cell lymphoma,Epithelium,Fibroblast,Keratinocyte,Kidney,Liver,Lymph,Placenta,Platelet,
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Research Areas:
>>Protein processing in endoplasmic reticulum ;
>>Phagosome ;
>>Antigen processing and presentation ;
>>Thyroid hormone synthesis ;
>>Human T-cell leukemia virus 1 infection
>>Phagosome ;
>>Antigen processing and presentation ;
>>Thyroid hormone synthesis ;
>>Human T-cell leukemia virus 1 infection
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM0089
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
Collect
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