Synthesized peptide derived from human PP2B-Aα

This antibody detects endogenous levels of Human,Mouse,Rat PP2B-Aα

PPP3CA CALNA CNA

PP2B-Aα

Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform ;
CAM-PRP catalytic subunit ;
Calmodulin-dependent calcineurin A subunit alpha isoform ;

catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 Fe(3+) ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.,online information:Calcineurin entry,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-2B subfamily.,subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.,subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.,

Catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 Fe(3+) ion per subunit.,cofactor:Binds 1 zinc ion per subunit.,Function:Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates HSPB1 and SSH1.,online information:Calcineurin entry,similarity:Belongs to the PPP phosphatase family.,similarity:Belongs to the PPP phosphatase family. PP-2B subfamily.,subcellular location:Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle.,subunit:Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. Interacts with TORC2/CRTC2, MYOZ1, MYOZ2 and MYOZ3.,

Cytoplasm . Cell membrane ; Peripheral membrane protein . Cell membrane, sarcolemma . Cytoplasm, myofibril, sarcomere, Z line . Cell projection, dendritic spine . Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle (By similarity). Recruited to the cell membrane by scaffold protein AKAP5 following L-type Ca(2+)-channel activation (PubMed:22343722). .

Expressed in keratinocytes (at protein level) (PubMed:29043977). Expressed in lymphoblasts (at protein level) (PubMed:30254215).

>>MAPK signaling pathway ;
>>Calcium signaling pathway ;
>>cGMP-PKG signaling pathway ;
>>Oocyte meiosis ;
>>Cellular senescence ;
>>Wnt signaling pathway ;
>>Axon guidance ;
>>VEGF signaling pathway ;
>>Osteoclast differentiation ;
>>C-type lectin receptor signaling pathway ;
>>Natural killer cell mediated cytotoxicity ;
>>Th1 and Th2 cell differentiation ;
>>Th17 cell differentiation ;
>>T cell receptor signaling pathway ;
>>B cell receptor signaling pathway ;
>>Long-term potentiation ;
>>Glutamatergic synapse ;
>>Dopaminergic synapse ;
>>Oxytocin signaling pathway ;
>>Glucagon signaling pathway ;
>>Renin secretion ;
>>Alzheimer disease ;
>>Amyotrophic lateral sclerosis ;
>>Prion disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Amphetamine addiction ;
>>Tuberculosis ;
>>Human cytomegalovirus infection ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Human immunodeficiency virus 1 infection ;
>>PD-L1 expression and PD-1 checkpoint pathway in cancer ;
>>Lipid and atherosclerosis