Synthesized peptide derived from human GCK/GLK. at AA range: 221-270

GCK/GLK Polyclonal Antibody detects endogenous levels of GCK/GLK

MAP4K2/MAP4K3

GCK/GLK

Mitogen-activated protein kinase kinase kinase kinase 2 ;
B lymphocyte serine/threonine-protein kinase ;
Germinal center kinase ;
GC kinase ;
MAPK/ERK kinase kinase kinase 2 ;
MEK kinase kinase 2 ;
MEKKK 2 ;
Rab8-interacting protein ;
Mitogen-activated protein kinase kinase kinase kinase 3 ;
Germinal center kinase-related protein kinase ;
GLK ;
MAPK/ERK kinase kinase kinase 3 ;
MEK kinase kinase 3 ;
MEKKK 3 ;

mitogen-activated protein kinase kinase kinase kinase 2(MAP4K2) Homo sapiens The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015],

Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,Function:Enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion.,sequence Caution:Contaminating sequence. Sequence of unknown origin in the N-terminal part.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.,similarity:Contains 1 CNH domain.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with TRAF2, MAP3K1 and RAB8A.,tissue specificity:Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined.,

Cytoplasm . Basolateral cell membrane ; Peripheral membrane protein . Golgi apparatus membrane ; Peripheral membrane protein .

>>MAPK signaling pathway