Catalog: YT3734
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
PIP5K
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF
MW
237kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-300; IF 1:200-1:1000;
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
PIP5KIII Polyclonal Antibody detects endogenous levels of PIP5KIII protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
237kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
Related Products
Primary Antibodies
PIP5KIII Rabbit pAb
YT3734
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PIP5KIII (Phospho Ser307) Rabbit pAb
YP1162
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ELISA Kits
Total PIP5K Cell-Based Colorimetric ELISA Kit
KA4234C
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human PIP5K. AA range:71-120
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Specificity:
PIP5KIII Polyclonal Antibody detects endogenous levels of PIP5KIII protein.
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Gene Name:
PIKFYVE
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Protein Name:
1-phosphatidylinositol 3-phosphate 5-kinase
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Other Name:
PIKFYVE ;
KIAA0981 ;
PIP5K3 ;
1-phosphatidylinositol 3-phosphate 5-kinase ;
Phosphatidylinositol 3-phosphate 5-kinase ;
FYVE finger-containing phosphoinositide kinase ;
PIKfyve ;
Phosphatidylinositol 3-phosphate 5-kinase type III ;
PIPkin-III ;
Type
KIAA0981 ;
PIP5K3 ;
1-phosphatidylinositol 3-phosphate 5-kinase ;
Phosphatidylinositol 3-phosphate 5-kinase ;
FYVE finger-containing phosphoinositide kinase ;
PIKfyve ;
Phosphatidylinositol 3-phosphate 5-kinase type III ;
PIPkin-III ;
Type
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Background:
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKf
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Function:
Catalytic activity:ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.,Disease:Defects in PIKFYVE are the cause of corneal fleck dystrophy (CFD) [MIM:121850]. CFD is an autosomal dominant disorder of the cornea characterized by numerous small white flecks scattered in all levels of the stroma. Although CFD may occasionally cause mild photophobia, patients are typically asymptomatic and have normal vision.,Function:Supports the intracellular PIP pool and to a lesser extent, the PI 4,5-P(2) pool. It generates PIP from PI and, to a lesser extent, PI 4,5-P(2) from PI 4-P. There are indications that it phosphorylates the D-5 rather than the D-4 position. Has a role in endosome-related membrane trafficking.,similarity:Contains 1 DEP domain.,similarity:Contains 1 FYVE-type zinc finger.,similarity:Contains 1 PI5K domain.,subcellular location:Mainly associated with membranes of the late endocytic pathway.,
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Cellular Localization:
Endosome membrane ; Peripheral membrane protein . Early endosome membrane ; Peripheral membrane protein. Cytoplasmic vesicle, phagosome membrane ; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein . Mainly associated with membranes of the late endocytic pathway. .
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Tissue Expression:
Research Areas:
>>Inositol phosphate metabolism ;
>>Metabolic pathways ;
>>Phosphatidylinositol signaling system ;
>>Phagosome ;
>>Regulation of actin cytoskeleton
>>Metabolic pathways ;
>>Phosphatidylinositol signaling system ;
>>Phagosome ;
>>Regulation of actin cytoskeleton
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT3734
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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