Synthesized peptide derived from PC-PLD2 . at AA range: 110-190

PC-PLD2 Polyclonal Antibody detects endogenous levels of PC-PLD2 protein.

PLD2

Phospholipase D2

PLD2 ;
Phospholipase D2 ;
PLD 2 ;
hPLD2 ;
Choline phosphatase 2 ;
PLD1C ;
Phosphatidylcholine-hydrolyzing phospholipase D2

The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011],

Catalytic activity:A phosphatidylcholine + H(2)O = choline + a phosphatidate.,enzyme regulation:Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation factor-1 (ARF-1).,Function:May have a role in signal-induced cytoskeletal regulation and/or endocytosis.,online information:Phospholipase D entry,similarity:Belongs to the phospholipase D family.,similarity:Contains 1 PH domain.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 PLD phosphodiesterase domains.,subunit:Interacts with EGFR (By similarity). Interacts with PIP5K1A.,tissue specificity:Ubiquitous.,

Cell membrane ; Lipid-anchor .

>>Glycerophospholipid metabolism ;
>>Ether lipid metabolism ;
>>Metabolic pathways ;
>>Ras signaling pathway ;
>>cAMP signaling pathway ;
>>Sphingolipid signaling pathway ;
>>Phospholipase D signaling pathway ;
>>Endocytosis ;
>>Fc gamma R-mediated phagocytosis ;
>>Glutamatergic synapse ;
>>GnRH signaling pathway ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Pathways in cancer ;
>>Chemical carcinogenesis - reactive oxygen species ;
>>Pancreatic cancer ;
>>Choline metabolism in cancer