Catalog: YT3495
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
Main Information
Target
p18
Host Species
Rabbit
Reactivity
Human, Mouse, Monkey
Applications
WB, IHC, IF, ELISA
MW
18kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
p18 Polyclonal Antibody detects endogenous levels of p18 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
18kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human p18 INK. AA range:111-160
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Specificity:
p18 Polyclonal Antibody detects endogenous levels of p18 protein.
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Gene Name:
CDKN2C
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Protein Name:
Cyclin-dependent kinase 4 inhibitor C
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Other Name:
CDKN2C ;
CDKN6 ;
Cyclin-dependent kinase 4 inhibitor C ;
Cyclin-dependent kinase 6 inhibitor ;
p18-INK4c ;
p18-INK6
CDKN6 ;
Cyclin-dependent kinase 4 inhibitor C ;
Cyclin-dependent kinase 6 inhibitor ;
p18-INK4c ;
p18-INK6
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Background:
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008],
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Function:
Disease:Defects in CDKN2C are involved in tumor formation.,Function:Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.,similarity:Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.,similarity:Contains 4 ANK repeats.,subunit:Heterodimer of p18 with CDK6.,tissue specificity:Highest levels found in skeletal muscle. Also found in pancreas and heart.,
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Cellular Localization:
nucleus,cytoplasm,cytosol,
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Tissue Expression:
Research Areas:
>>Endocrine resistance ;
>>Cell cycle ;
>>Cushing syndrome ;
>>Human T-cell leukemia virus 1 infection ;
>>Transcriptional misregulation in cancer
>>Cell cycle ;
>>Cushing syndrome ;
>>Human T-cell leukemia virus 1 infection ;
>>Transcriptional misregulation in cancer
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT3495
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
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