Catalog: YT0396
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
Atg4D
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, IHC, IF, ELISA
MW
45kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:5000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Atg4D Polyclonal Antibody detects endogenous levels of Atg4D protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
45kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from the Internal region of human Atg4D.
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Specificity:
Atg4D Polyclonal Antibody detects endogenous levels of Atg4D protein.
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Gene Name:
ATG4D
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Protein Name:
Cysteine protease ATG4D
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Other Name:
ATG4D ;
APG4D ;
AUTL4 ;
Cysteine protease ATG4D ;
AUT-like 4 cysteine endopeptidase ;
Autophagin-4 ;
Autophagy-related cysteine endopeptidase 4 ;
Autophagy-related protein 4 homolog D
APG4D ;
AUTL4 ;
Cysteine protease ATG4D ;
AUT-like 4 cysteine endopeptidase ;
Autophagin-4 ;
Autophagy-related cysteine endopeptidase 4 ;
Autophagy-related protein 4 homolog D
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Background:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
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Function:
enzyme regulation:Inhibited by N-ethylmaleimide.,Function:Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.,similarity:Belongs to the peptidase C54 family.,tissue specificity:Mainly expressed in skeletal muscle and, to a lower extent, in testis.,
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Cellular Localization:
[Cysteine protease ATG4D]: Cytoplasm .; [Cysteine protease ATG4D, mitochondrial]: Cytoplasm . Mitochondrion matrix . Imported into mitochondrial matrix after cleavage by CASP3 during oxidative stress and cell death. .
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Tissue Expression:
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Research Areas:
>>Autophagy - other ;
>>Autophagy - animal
>>Autophagy - animal
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Signaling Pathway
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Catalog: YT0396
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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