Catalog: YM8031
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
Collect
Main Information
Target
Cdc37
Host Species
Rabbit
Reactivity
Human, Mouse, Rat,
Applications
WB, IHC, IF, IP, ELISA
MW
44kD (Calculated)
44kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
IHC 1:400-1000; WB 1:1000-5000; IF 1:200-1000; ELISA 1:5000-20000; IP 1:50-200
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
This antibody detects endogenous levels of CDC37 only when phosphorylated at Ser13.
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
44kD
MW(Observed)
44kD
Modification
Phospho
Clonality
Monoclonal
Clone Number
PT0060R
Isotype
IgG,Kappa
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Antigen&Target Information
Specificity:
This antibody detects endogenous levels of CDC37 only when phosphorylated at Ser13.
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Gene Name:
CDC37
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Protein Name:
Hsp90 co-chaperone Cdc37
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Other Name:
CDC37 ;
CDC37A ;
Hsp90 co-chaperone Cdc37 ;
Hsp90 chaperone protein kinase-targeting subunit ;
p50Cdc37
CDC37A ;
Hsp90 co-chaperone Cdc37 ;
Hsp90 chaperone protein kinase-targeting subunit ;
p50Cdc37
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Database Link:
Background:
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008],
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Function:
Function:Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity.,PTM:Constitutively sumoylated by UBE2I.,similarity:Belongs to the CDC37 family.,subunit:Forms a complex with Hsp90. Interacts with AR, CDK4, CDK6, EIF2AK1 and RB1.,
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Cellular Localization:
Cytoplasm
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Tissue Expression:
Lymph,Placenta,
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Research Areas:
>>PI3K-Akt signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM8031
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
Collect
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