Catalog: YM0509
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
Pax-8
Host Species
Mouse
Reactivity
Human
Applications
WB, ELISA
MW
48kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Pax-8 Monoclonal Antibody detects endogenous levels of Pax-8 protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
48kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
4H15
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Antigen&Target Information
Immunogen:
Purified recombinant fragment of human Pax-8 expressed in E. Coli.
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Specificity:
Pax-8 Monoclonal Antibody detects endogenous levels of Pax-8 protein.
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Gene Name:
PAX8
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Protein Name:
Paired box protein Pax-8
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Other Name:
PAX8 ;
Paired box protein Pax-8
Paired box protein Pax-8
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Background:
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],
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Function:
Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,developmental stage:In developing excretory system, during thyroid differentiation and in adult thyroid.,Disease:Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.,Function:Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.,similarity:Contains 1 paired domain.,tissue specificity:Expressed in the excretory system, thyroid gland and Wilms tumors.,
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Cellular Localization:
Nucleus.
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Tissue Expression:
Research Areas:
>>Thyroid hormone synthesis ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Thyroid cancer
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Thyroid cancer
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Phagosome
Cellular Processes >> Cell growth and death >> Apoptosis
Cellular Processes >> Cellular community - eukaryotes >> Tight junction
Cellular Processes >> Cellular community - eukaryotes >> Gap junction
Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Human Diseases >> Neurodegenerative disease >> Parkinson disease
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Huntington disease
Human Diseases >> Neurodegenerative disease >> Prion disease
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
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Catalog: YM0509
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
Collect
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