PAX-8 (4H15) Mouse mAb

-YM0509

Catalog: YM0509
Size
Price
Status
Qty.
200μL
$600.00
3 weeks

0

100μL
$350.00
3 weeks

0

50μL
$210.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service
Main Information
Target

Pax-8

Host Species

Mouse

Reactivity

Human

Applications

WB, ELISA

MW

48kD (Calculated)

Conjugate/Modification


Unmodified

Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Pax-8 Monoclonal Antibody detects endogenous levels of Pax-8 protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
48kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
4H15
Related Products
Primary Antibodies
PAX-8 Rabbit pAb
YT3602

More→

Primary Antibodies
PAX-8 (4H15) Mouse mAb
YM0509

More→

Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001

More→

Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002

More→

Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028

More→

Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029

More→

Antigen&Target Information
Immunogen:
Purified recombinant fragment of human Pax-8 expressed in E. Coli.
show all
Specificity:
Pax-8 Monoclonal Antibody detects endogenous levels of Pax-8 protein.
show all
Gene Name:
PAX8
show all
Protein Name:
Paired box protein Pax-8
show all
Other Name:
PAX8 ;
Paired box protein Pax-8
show all
Database Link:
Organism Gene ID SwissProt
Human 7846; Q06710;
Mouse Q00288;
Background:
This gene encodes a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010],
show all
Function:
Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,developmental stage:In developing excretory system, during thyroid differentiation and in adult thyroid.,Disease:Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) [MIM:218700]. CHNG2 is a disease characterized by thyroid dysgenesis, the most frequent cause of congenital hypothyroidism, accounting for 85% of case. The thyroid gland can be completely absent (athyreosis), ectopically located and/or severely hypoplastic. Ectopic thyroid gland is the most frequent malformation, with thyroid tissue being found most often at the base of the tongue.,Function:Transcription factor for the thyroid-specific expression of the genes exclusively expressed in the thyroid cell type, maintaining the functional differentiation of such cells.,similarity:Contains 1 paired domain.,tissue specificity:Expressed in the excretory system, thyroid gland and Wilms tumors.,
show all
Cellular Localization:
Nucleus.
show all
Research Areas:
>>Thyroid hormone synthesis ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Thyroid cancer
show all
Catalog: YM0509
Size
Price
Status
Qty.
200μL
$600.00
3 weeks

0

100μL
$350.00
3 weeks

0

50μL
$210.00
3 weeks

0

Add to cart

Collected

Collect

Customized Service

Toggle night Mode

{{pinfoXq.title || ''}}

Catalog: {{pinfoXq.catalog || ''}}
Filter:

All

{{item.name}}

{{pinfo.title}}
-{{pinfo.catalog}}

Filter:

{{item.descr}}

Main Information
Target
{{pinfo.target}}
Reactivity
{{pinfo.react}}
Applications
{{pinfo.applicat}}
Conjugate/Modification
{{pinfo.coupling}}/{{pinfo.modific}}
MW (kDa)
{{pinfo.mwcalc}}
Host Species
{{pinfo.hostspec}}
Isotype
{{pinfo.isotype}}
Learn more
Product {{index}}/{{pcount}}
Prev
Next

{{pvTitle}}

Scroll wheel zooms the picture
{{pvDescr}}