Catalog: YM0434
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
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Main Information
Target
MAP3K2
Host Species
Mouse
Reactivity
Human
Applications
WB, IF, ELISA
MW
70kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
MEK Kinase-2 Monoclonal Antibody detects endogenous levels of MEK Kinase-2 protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
70kD
Modification
Unmodified
Clonality
Monoclonal
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Antigen&Target Information
Immunogen:
Purified recombinant fragment of human MEK Kinase-2 expressed in E. Coli.
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Specificity:
MEK Kinase-2 Monoclonal Antibody detects endogenous levels of MEK Kinase-2 protein.
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Gene Name:
MAP3K2
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Protein Name:
Mitogen-activated protein kinase kinase kinase 2
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Other Name:
MAP3K2 ;
MAPKKK2 ;
MEKK2 ;
Mitogen-activated protein kinase kinase kinase 2 ;
MAPK/ERK kinase kinase 2 ;
MEK kinase 2 ;
MEKK 2
MAPKKK2 ;
MEKK2 ;
Mitogen-activated protein kinase kinase kinase 2 ;
MAPK/ERK kinase kinase 2 ;
MEK kinase 2 ;
MEKK 2
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Background:
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008],
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Function:
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-524.,Function:Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 OPR domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Upon EGF stimulation, translocates into the nucleus.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,
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Cellular Localization:
Cytoplasm . Nucleus . Upon EGF stimulation, translocates into the nucleus.
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Tissue Expression:
Brain,Platelet,T-cell,Teratocarcinoma,Whole embryo,
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Research Areas:
>>MAPK signaling pathway ;
>>Gap junction ;
>>GnRH signaling pathway
>>Gap junction ;
>>GnRH signaling pathway
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM0434
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
Collect
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