Synthesized peptide derived from human MUM1 AA range: 350-451

The antibody can specifically recognize human MUM1 protein.

IRF4 MUM1

Interferon regulatory factor 4

Interferon regulatory factor 4 ;
IRF 4 ;
IRF-4 ;
Irf4 ;
IRF4_HUMAN ;
LSIRF ;
Lymphocyte specific interferon regulatory factor ;
Lymphocyte specific IRF ;
Lymphocyte-specific interferon regulatory factor ;
Multiple myeloma oncogene 1 ;
MUM 1 ;
MUM1 ;
NF EM5 ;
NF-EM5 ;
NFEM5 ;
PU.1 interaction partner ;
Sfpi1/PU.1 interaction partner ;
Transcriptional activator PIP

MUM1, also known as interferon regulatory factor 4, with a molecular weight of 50 kDa, is a nuclear transcription factor necessary for the development and activation of B lymphocytes. It can regulate the proliferation and differentiation of B cells and activate T lymphocytes. It is mainly used for the study of B-cell lymphoma. It is expressed in multiple myeloma, lymphoplasmacytic lymphoma and diffuse large B-cell lymphoma. It can be used as a tissue derived immunophenotypic marker of B-cell lymphoma. At the same time, it is also expressed in RS cells in anaplastic large cell lymphoma, peripheral T-cell lymphoma and classical Hodgkin's lymphoma. It is an immunophenotypic marker of malignant lymphoma, only limited to lymphocytes and melanocytes.

Disease:A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus.,Function:Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.,induction:Not induced by interferons.,similarity:Belongs to the IRF family.,similarity:Contains 1 tryptophan pentad repeat DNA-binding domain.,subunit:Interacts with SPIB and DEF6.,tissue specificity:Lymphoid cells.,

Nuclear

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