Catalog: YM8016
Size
Price
Status
Qty.
1mL
$1,360.00
3 weeks
0
500μL
$800.00
3 weeks
0
100μL
$184.00
3 weeks
0
Add to cart
Collected
Collect
Conjugated antibody
GAPDH (2B8) Mouse mAb (AbFluor 350)
GAPDH (2B8) Mouse mAb (AbFluor 405)
GAPDH (2B8) Mouse mAb (AbFluor 488)
GAPDH (2B8) Mouse mAb (AbFluor 555)
GAPDH (2B8) Mouse mAb (AbFluor 594)
GAPDH (2B8) Mouse mAb (AbFluor 647)
GAPDH (2B8) Mouse mAb (AbFluor 680)
GAPDH (2B8) Mouse mAb (Biotin)
GAPDH (2B8) Mouse mAb (Cy3)
GAPDH (2B8) Mouse mAb (Cy5)
GAPDH (2B8) Mouse mAb (FITC)
GAPDH (2B8) Mouse mAb (HRP)
Main Information
Target
GAPDH
Host Species
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Monkey
Applications
WB, ELISA
MW
37kD (Calculated)
37kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; ELISA 1:20000
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year (Do not lower than -25°C)
MW(Calculated)
37kD
MW(Observed)
37kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0004R
Isotype
IgG, Kappa
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RS0002
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Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
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Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human protein. AA range:200-300
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Specificity:
Endogenous
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Gene Name:
GAPDH
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Protein Name:
Glyceraldehyde-3-phosphate dehydrogenase
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Other Name:
GAPDH ;
GAPD ;
CDABP0047 ;
OK/SW-cl.12 ;
Glyceraldehyde-3-phosphate dehydrogenase ;
GAPDH ;
Peptidyl-cysteine S-nitrosylase GAPDH
GAPD ;
CDABP0047 ;
OK/SW-cl.12 ;
Glyceraldehyde-3-phosphate dehydrogenase ;
GAPDH ;
Peptidyl-cysteine S-nitrosylase GAPDH
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Database Link:
Background:
glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Homo sapiens This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism , the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD) . The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also , this protein contains a peptide that has antimicrobial activity against E. coli , P. aeruginosa , and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins , the regulation of mRNA stability , and acting as a transferri
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Function:
Catalytic activity:D-glyceraldehyde 3-phosphate + phosphate + NAD (+) = 3-phospho-D-glyceroyl phosphate + NADH. ,Function:Independent of its glycolytic activity it is also involved in membrane trafficking in the early secretory pathway. ,online information:Glyceraldehyde 3-phosphate dehydrogenase entry ,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1. ,pathway:Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. ,PTM:Reversible S-nitrosylation of Cys-152 inhibits enzymatic activity and increases endogenous ADP-ribosylation , which inhibits the enzyme in a non-reversible manner. The latter modification is more likely to be a pathophysiological event associated with inhibition of gluconeogenesis. ,sequence Caution:Differs quite extensively. ,similarity:Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. ,subcellular location:Postnuclear and Perinuclear regions. ,subunit:Homotetramer. ,subunit:Homotetramer. Binds PRKCI. ,
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Cellular Localization:
Cytoplasm , cytosol . Nucleus . Cytoplasm , perinuclear region . Membrane . Cytoplasm , cytoskeleton . Translocates to the nucleus following S-nitrosylation and interaction with SIAH1 , which contains a nuclear localization signal (By similarity) . Postnuclear and Perinuclear regions (PubMed:12829261) . .
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Tissue Expression:
Research Areas:
>>Glycolysis / Gluconeogenesis ;
>>Metabolic pathways ;
>>Carbon metabolism ;
>>Biosynthesis of amino acids ;
>>HIF-1 signaling pathway ;
>>Alzheimer disease ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection ;
>>Diabetic cardiomyopathy
>>Metabolic pathways ;
>>Carbon metabolism ;
>>Biosynthesis of amino acids ;
>>HIF-1 signaling pathway ;
>>Alzheimer disease ;
>>Pathogenic Escherichia coli infection ;
>>Salmonella infection ;
>>Diabetic cardiomyopathy
show all
Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM8016
Size
Price
Status
Qty.
1mL
$1,360.00
3 weeks
0
500μL
$800.00
3 weeks
0
100μL
$184.00
3 weeks
0
Add to cart
Collected
Collect
Conjugated antibody
GAPDH (2B8) Mouse mAb (AbFluor 350)
GAPDH (2B8) Mouse mAb (AbFluor 405)
GAPDH (2B8) Mouse mAb (AbFluor 488)
GAPDH (2B8) Mouse mAb (AbFluor 555)
GAPDH (2B8) Mouse mAb (AbFluor 594)
GAPDH (2B8) Mouse mAb (AbFluor 647)
GAPDH (2B8) Mouse mAb (AbFluor 680)
GAPDH (2B8) Mouse mAb (Biotin)
GAPDH (2B8) Mouse mAb (Cy3)
GAPDH (2B8) Mouse mAb (Cy5)
GAPDH (2B8) Mouse mAb (FITC)
GAPDH (2B8) Mouse mAb (HRP)
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