Catalog: YF0112
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Status
Qty.
10mg
$0.00
3 weeks
0
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Main Information
Target
TIM 3
Host Species
Mouse
Reactivity
Human
Applications
FC, IF
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IF 1:200-1:1000; FC:1 µg per million cells in 100 µl volume. For optimal results, the reagent should be titrated according to each specific application
Formulation
PBS, pH 7.4
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Concentration
0.5mg/ml
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PTF0116
Isotype
Mouse IgG1/Kappa
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Antigen&Target Information
Specificity:
Endogenous
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Gene Name:
HAVCR2 TIM3 TIMD3
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Protein Name:
Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell membrane protein 3) (TIM-3)
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Other Name:
TIM3 ;
CD366 ;
TIM-3 ;
SPTCL ;
TIMD3 ;
Tim-3 ;
TIMD-3 ;
HAVcr-2
CD366 ;
TIM-3 ;
SPTCL ;
TIMD3 ;
Tim-3 ;
TIMD-3 ;
HAVcr-2
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Background:
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011],
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Function:
Disease:Genetic variation in HAVCR2 may influence susceptibility to rheumatoid arthritis (RA) [MIM:180300]. RA is an inflammatory disease, primarily of the joints, with autoimmune features and a complex genetic component. It is characterized by inflammation of synovial tissues and the formation of rheumatoid pannus, which is capable of eroding adjacent cartilage and bone, causing subsequent joint destruction.,Function:Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.,similarity:Belongs to the immunoglobulin superfamily. TIM family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,tissue specificity:T-helper type 1 lymphocyte (Th1)-specific.,
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Cellular Localization:
Membrane ; Single-pass type I membrane protein . Cell junction . Cell membrane . Localizes to the immunological synapse between CD8+ T-cells and target cells. .
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Reference Citation({{totalcount}})
Catalog: YF0112
Size
Price
Status
Qty.
10mg
$0.00
3 weeks
0
Add to cart
Collected
Collect
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