Catalog: YT3993
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
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Main Information
Target
RAGE
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
37kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
RAGE Polyclonal Antibody detects endogenous levels of RAGE protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
37kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
Related Products
Primary Antibodies
RAGE Rabbit pAb
YT3993
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ELISA Kits
Human RAGE ELISA Kit
KE1245
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Secondary Antibodies
Goat Anti Mouse IgG(H+L) (HRP)
RS0001
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Secondary Antibodies
Goat Anti Rabbit IgG(H+L) (HRP)
RS0002
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Primary Antibodies
β-actin (PTR2364) Mouse mAb
YM3028
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Primary Antibodies
GAPDH (PTR2304) Mouse mAb
YM3029
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human RAGE. AA range:133-182
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Specificity:
RAGE Polyclonal Antibody detects endogenous levels of RAGE protein.
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Gene Name:
AGER
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Protein Name:
Advanced glycosylation end product-specific receptor
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Other Name:
AGER ;
RAGE ;
Advanced glycosylation end product-specific receptor ;
Receptor for advanced glycosylation end products
RAGE ;
Advanced glycosylation end product-specific receptor ;
Receptor for advanced glycosylation end products
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Background:
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011],
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Function:
Function:Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Receptor for amyloid beta peptide.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Endothelial cells.,
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Cellular Localization:
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 10]: Cell membrane ; Single-pass type I membrane protein .
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Tissue Expression:
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Research Areas:
>>Neutrophil extracellular trap formation ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis
>>AGE-RAGE signaling pathway in diabetic complications ;
>>Alzheimer disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Diabetic cardiomyopathy ;
>>Lipid and atherosclerosis
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT3993
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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