Catalog: YM8072
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
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Collected
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Main Information
Target
LC3A
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, IP, ELISA
MW
14kD (Calculated)
16kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
IHC 1:200-1:1000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200,
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
Endogenous
Purification
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
14kD
MW(Observed)
16kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
PT0130R
Isotype
IgG,Kappa
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Antigen&Target Information
Immunogen:
The specific immunogen used to produce this antibody is proprietary information.
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Specificity:
Endogenous
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Gene Name:
MAP1LC3A
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Protein Name:
LC3A
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Other Name:
Microtubule-associated proteins 1A/1B light chain 3A ;
Autophagy-related protein LC3 A ;
Autophagy-related ubiquitin-like modifier LC3 A ;
MAP1 light chain 3-like protein 1 ;
MAP1A/MAP1B light chain 3 A ;
MAP1A/MAP1B LC3 A ;
Microtubule-associated protein 1 light chain 3 alpha ;
Autophagy-related protein LC3 A ;
Autophagy-related ubiquitin-like modifier LC3 A ;
MAP1 light chain 3-like protein 1 ;
MAP1A/MAP1B light chain 3 A ;
MAP1A/MAP1B LC3 A ;
Microtubule-associated protein 1 light chain 3 alpha ;
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Background:
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012],
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Function:
Function:Probably involved in formation of autophagosomal vacuoles (autophagosomes).,PTM:The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.,similarity:Belongs to the MAP1 LC3 family.,subcellular location:LC3-II binds to the autophagic membranes.,subunit:3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.,tissue specificity:Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.,
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Cellular Localization:
Cytoplasm
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Tissue Expression:
Research Areas:
>>Mitophagy - animal ;
>>Autophagy - animal ;
>>Ferroptosis ;
>>Apelin signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis ;
>>Kaposi sarcoma-associated herpesvirus infection
>>Autophagy - animal ;
>>Ferroptosis ;
>>Apelin signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>Amyotrophic lateral sclerosis ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Shigellosis ;
>>Kaposi sarcoma-associated herpesvirus infection
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Signaling Pathway
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Cellular Processes >> Transport and catabolism >> Mitophagy - animal
Cellular Processes >> Cell growth and death >> Ferroptosis
Organismal Systems >> Immune system >> NOD-like receptor signaling pathway
Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis
Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Reference Citation({{totalcount}})
Catalog: YM8072
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
Collect
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