The antiserum was produced against synthesized peptide derived from human ICAM-1. AA range:479-528

ICAM-1 Polyclonal Antibody detects endogenous levels of ICAM-1 protein.

ICAM1

Intercellular adhesion molecule 1

ICAM1 ;
Intercellular adhesion molecule 1 ;
ICAM-1 ;
Major group rhinovirus receptor ;
CD antigen CD54

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008],

Function:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.,online information:ICAM-1,online information:Icosahedral capsid structure,online information:Intercellular adhesion molecule entry,polymorphism:Homozygotes with ICAM1-Kalifi Met-56 seem to have an increased risk for cerebral malaria.,PTM:Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 5 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Homodimer (Probable). Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with SGEF. Binds to coxsackievirus A21 capsid proteins and acts as a receptor for this virus.,

Membrane; Single-pass type I membrane protein.

>>NF-kappa B signaling pathway ;
>>Cell adhesion molecules ;
>>Natural killer cell mediated cytotoxicity ;
>>TNF signaling pathway ;
>>Leukocyte transendothelial migration ;
>>AGE-RAGE signaling pathway in diabetic complications ;
>>African trypanosomiasis ;
>>Malaria ;
>>Staphylococcus aureus infection ;
>>Influenza A ;
>>Human T-cell leukemia virus 1 infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Epstein-Barr virus infection ;
>>Rheumatoid arthritis ;
>>Viral myocarditis ;
>>Lipid and atherosclerosis ;
>>Fluid shear stress and atherosclerosis