Catalog: YM8038
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
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Main Information
Target
Cyclin B1 Phospho Ser126
Host Species
Rabbit
Reactivity
Human
Applications
WB, IHC, IF, IP, ELISA
MW
48kD (Calculated)
55kD (Observed)
Conjugate/Modification
Phospho
Detailed Information
Recommended Dilution Ratio
IHC 1:500-1:2000; WB 1:1000-1:5000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200,
Formulation
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Specificity
This antibody detects endogenous levels of Cyclin B1 only when phosphorylated at Ser126.This antibody does not recognize phosphorylated at other sites.
Purification
Protein A
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
48kD
MW(Observed)
55kD
Modification
Phospho
Clonality
Monoclonal
Clone Number
PT0070R
Isotype
IgG,Kappa
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Antigen&Target Information
Sequence:
G2/mitotic-specific cyclin-B1
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Specificity:
This antibody detects endogenous levels of Cyclin B1 only when phosphorylated at Ser126.This antibody does not recognize phosphorylated at other sites.
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Gene Name:
CCNB1 CCNB
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Protein Name:
G2/mitotic-specific cyclin-B1
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Other Name:
CCNB1 ;
CCNB ;
G2/mitotic-specific cyclin-B1
CCNB ;
G2/mitotic-specific cyclin-B1
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Database Link:
Background:
The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008],
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Function:
developmental stage:Accumulates steadily during G2 and is abruptly destroyed at mitosis.,Function:Essential for the control of the cell cycle at the G2/M (mitosis) transition.,PTM:Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.,similarity:Belongs to the cyclin family.,similarity:Belongs to the cyclin family. Cyclin AB subfamily.,subunit:Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase.,
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Cellular Localization:
Cytoplasm, Nuclear
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Tissue Expression:
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YM8038
Size
Price
Status
Qty.
200μL
$600.00
In stock
0
100μL
$340.00
In stock
0
40μL
$190.00
In stock
0
Add to cart
Collected
Collect
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