Synthesized peptide derived from human DEAF1 AA range: 515-565

This antibody detects endogenous levels of DEAF1 at Human/Mouse/Rat

DEAF1 SPN ZMYND5

DEAF1

Deformed epidermal autoregulatory factor 1 homolog ;
Nuclear DEAF-1-related transcriptional regulator ;
NUDR ;
Suppressin ;
Zinc finger MYND domain-containing protein 5 ;

This gene encodes a zinc finger domain-containing protein that functions as a regulator of transcription. The encoded proteins binds to its own promoter as well as to that of several target genes. Activity of this protein is important in the regulation of embryonic development. Mutations in this gene have been found in individuals with autosomal dominant mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],

Alternative products:Experimental confirmation may be lacking for some isoforms,Caution:This protein was first known as suppressin (characterized in bovine neuroendocrine and immune cells). However, according to PubMed:9773984, it is uncertain whether it corresponds really to the suppressin also described in Ref.3. DEAF1 has been described as a nuclear dimeric protein and suppressin as a secreted monomeric protein.,Disease:Defects in DEAF1 could confer a growth advantage to the mutated cell that may have implications for the development and progression of neoplasia, e.g. in the case of colorectal adenocarcinomas (CRC).,Function:Transcription factor that binds to sequence with multiple copies of TTC[CG]G present in its own promoter and that of the HNRPA2B1 gene. Down-regulates transcription of these genes. Binds to the retinoic acid response element (RARE) AGGGTTCACCGAAAGTTCA. Activates the proenkephalin gene independently of promoter binding, probably through protein-protein interaction. When secreted, behaves as an inhibitor of cell proliferation, by arresting cells in the G0 or G1 phase.,miscellaneous:Subcellular location in CRC (cytoplasmic or nuclear) is a prognostic factor that identifies a subgroup of patients with reduced survival. In addition, changes in the subcellular location correlates with the proliferative status of the cells.,similarity:Contains 1 MYND-type zinc finger.,similarity:Contains 1 SAND domain.,subcellular location:Cytoplasmic in non-mucinous colorectal carcinoma.,subcellular location:Secreted in some cell types.,subunit:Homodimer (Probable). Binds to LMO4 (via its C-terminus), LMO2 and CLIM2 (By similarity). May interact with the corepressor NCOR.,tissue specificity:Expressed in various tissues and cells such as in peripheral mononuclear cells and hormone-secreting pituitary cells.,

[Isoform 1]: Nucleus. Cytoplasm. Cytoplasmic in non-mucinous colorectal carcinoma. When expressed alone, localized almost exclusively in the nucleus but, when expressed with isoform 4, nuclear expression decreases to 32% and cytoplasmic expression increases by 270%.; [Isoform 2]: Secreted. Secreted in some cell types.; [Isoform 3]: Secreted. Secreted in some cell types.; [Isoform 4]: Cytoplasm. Nucleus. When expressed alone, localizes mainly in the cytoplasm but, when expressed with isoform 1, nuclear localization is enhanced.