Catalog: YM0400
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
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Collected
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Main Information
Target
KLHL12
Host Species
Mouse
Reactivity
Human
Applications
WB, ELISA
MW
63kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
KLHL12 Monoclonal Antibody detects endogenous levels of KLHL12 protein.
Purification
Affinity purification
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
MW(Calculated)
63kD
Modification
Unmodified
Clonality
Monoclonal
Clone Number
13B6
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Antigen&Target Information
Immunogen:
Purified recombinant fragment of human KLHL12 expressed in E. Coli.
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Specificity:
KLHL12 Monoclonal Antibody detects endogenous levels of KLHL12 protein.
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Gene Name:
KLHL12
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Protein Name:
Kelch-like protein 12
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Other Name:
KLHL12 ;
C3IP1 ;
Kelch-like protein 12 ;
CUL3-interacting protein 1 ;
DKIR homolog ;
hDKIR
C3IP1 ;
Kelch-like protein 12 ;
CUL3-interacting protein 1 ;
DKIR homolog ;
hDKIR
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Background:
This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014],
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Function:
Domain:The BTB domain is required for interaction with CUL3.,Function:Serves as a substrate-specific adapter for the CUL3-based ubiquitin-protein E3 ligase complex. Negatively regulates the Wnt signaling pathway via the targeted ubiquitination and subsequent proteolysis of DVL3.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Component of an ubiquitin-protein E3 ligase complex which includes at least CUL3 and KLHL12. This complex interacts with DVL3 upon activation of the Wnt signaling pathway by WNT3A.,tissue specificity:Highly expressed in testis and at lower levels in the submandibular salivary gland.,
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Cellular Localization:
Cytoplasmic vesicle, COPII-coated vesicle .
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Tissue Expression:
Reference Citation({{totalcount}})
Catalog: YM0400
Size
Price
Status
Qty.
200μL
$600.00
3 weeks
0
100μL
$350.00
3 weeks
0
50μL
$210.00
3 weeks
0
Add to cart
Collected
Collect
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