Purified recombinant fragment of IKKε (aa1-257) expressed in E. Coli.

IKKε Monoclonal Antibody detects endogenous levels of IKKε protein.

IKBKE IKKE IKKI KIAA0151

Inhibitor of nuclear factor kappa-B kinase subunit epsilon

IKBKE ;
IKKE ;
IKKI ;
KIAA0151 ;
Inhibitor of nuclear factor kappa-B kinase subunit epsilon ;
I-kappa-B kinase epsilon ;
IKK-E ;
IKK-epsilon ;
IkBKE ;
Inducible I kappa-B kinase ;
IKK-i

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009],

Catalytic activity:ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].,Function:Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response.,PTM:Autophosphorylated.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE.,tissue specificity:Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.,

Cytoplasm . Nucleus. Nucleus, PML body . Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent (PubMed:20188669). Located diffusely throughout the cytoplasm but locates to punctate cytoplasmic bodies when coexpressed with TRIM6 (PubMed:24882218). .

>>Toll-like receptor signaling pathway ;
>>NOD-like receptor signaling pathway ;
>>RIG-I-like receptor signaling pathway ;
>>Cytosolic DNA-sensing pathway ;
>>C-type lectin receptor signaling pathway ;
>>IL-17 signaling pathway ;
>>Alcoholic liver disease ;
>>Hepatitis C ;
>>Hepatitis B ;
>>Measles ;
>>Influenza A ;
>>Human papillomavirus infection ;
>>Kaposi sarcoma-associated herpesvirus infection ;
>>Herpes simplex virus 1 infection ;
>>Epstein-Barr virus infection ;
>>Coronavirus disease - COVID-19 ;
>>Chemical carcinogenesis - receptor activation ;
>>Lipid and atherosclerosis