Catalog: YC0044
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
Cathepsin G
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
28kD,26kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
Cleaved-Cathepsin G (I21) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin G protein resulting from cleavage adjacent to I21.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
28kD,26kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human CATG. AA range:2-51
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Specificity:
Cleaved-Cathepsin G (I21) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin G protein resulting from cleavage adjacent to I21.
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Gene Name:
CTSG
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Protein Name:
Cathepsin G
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Other Name:
CTSG ;
Cathepsin G ;
CG
Cathepsin G ;
CG
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Background:
The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014],
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Function:
Catalytic activity:Specificity similar to chymotrypsin C.,enzyme regulation:Inhibited by soybean trypsin inhibitor, benzamidine, the synthetic peptide R13K, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride. Inhibited by LPS from P.aeruginosa but not by LPS from S.minnesota.,Function:Serine protease with trypsin- and chymotrypsin-like specificity. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe-CH2Cl and phenylmethylsulfonyl fluoride.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,
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Cellular Localization:
Cell membrane ; Peripheral membrane protein . Cytoplasmic granule . Secreted . Cytoplasm, cytosol . Lysosome . Nucleus . Secreted by activated neutrophils (PubMed:3390156). Detected in synovial fluid (PubMed:32144329). Localizes to lysosomes in B cells where it is not endogenously synthesized but is internalized from the cell membrane (PubMed:15100291). Localizes to the nucleus during apoptosis (PubMed:11259672). .
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Tissue Expression:
Research Areas:
>>Neuroactive ligand-receptor interaction ;
>>Lysosome ;
>>Neutrophil extracellular trap formation ;
>>Renin-angiotensin system ;
>>Amoebiasis ;
>>Systemic lupus erythematosus
>>Lysosome ;
>>Neutrophil extracellular trap formation ;
>>Renin-angiotensin system ;
>>Amoebiasis ;
>>Systemic lupus erythematosus
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YC0044
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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