The antiserum was produced against synthesized peptide derived from human Aggrecan. AA range:320-369

Cleaved-Aggrecan (D369) Polyclonal Antibody detects endogenous levels of fragment of activated Aggrecan protein resulting from cleavage adjacent to D369.

ACAN AGC1 CSPG1 MSK16

Aggrecan core protein

ACAN ;
AGC1 ;
CSPG1 ;
MSK16 ;
Aggrecan core protein ;
Cartilage-specific proteoglycan core protein ;
CSPCP ;
Chondroitin sulfate proteoglycan core protein 1 ;
Chondroitin sulfate proteoglycan 1

This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008],

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Secreted, extracellular space, extracellular matrix .