Synthesized peptide derived from human AMACR AA range: 300-382

The antibody can specifically recognize human AMACR protein. In western blotting of Hela and LnCap cell lysates, the antibody can label a 42 kDa band corresponding to AMACR.

AMACR

AMACR

2 arylpropionyl CoA epimerase ;
2 methylacyl CoA racemase ;
2-methylacyl-CoA racemase ;
Alpha methylacyl CoA racemase ;
Alpha methylacyl Coenzyme A racemase ;
Alpha methylacyl-CoA racemase deficiency, included ;
Alpha-methylacyl-CoA racemase ;
Amacr ;
AMACR deficiency, included ;
AMACR_HUMAN ;
CBAS4 ;
Da1-8 ;
Macr1 ;
Methylacyl CoA racemase alpha ;
RACE ;
RM

AMACR is an α Formyl COA racemase localized in peroxisomes and mitochondria . It is an enzyme involved in biosynthesis of bile acid and β-oxidation of branched-chain fatty acids. It is expressed in the epithelium and salivary gland of proximal convoluted tubules of pancreas, liver and kidney, and moderately in paraurethral glands. The expression in prostate cancer is higher than that in benign prostate tissue. In the study of prostate cancer, it is often used in combination with PSA, p63, 34 β E12 and other antibodies.

Catalytic activity:(2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA.,Disease:Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) [MIM:604489]. AMACRD results in elevated plasma concentrations of pristanic acid C27-bile-acid intermediates. It can be associated with polyneuropathy, retinitis pigmentosa, epilepsy.,Disease:Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) [MIM:214950]; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.,Function:Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.,pathway:Lipid metabolism; bile acid biosynthesis.,pathway:Lipid metabolism; fatty acid metabolism.,similarity:Belongs to the caiB/baiF CoA-transferase family.,similarity:Contains 1 C1q domain.,similarity:Contains 1 collagen-like domain.,

Cytoplasmic

>>Primary bile acid biosynthesis ;
>>Metabolic pathways ;
>>Peroxisome