Catalog: YT8130
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
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Main Information
Target
SLC7A11
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
IHC, WB
MW
35kD (Calculated)
35kD or 55kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; IHC 1:50-200
Formulation
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of XCT at Human, Mouse
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
35kD
MW(Observed)
35kD or 55kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human N-ternal XCT
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Specificity:
This antibody detects endogenous levels of XCT at Human, Mouse
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Gene Name:
SLC7A11
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Protein Name:
Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)
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Other Name:
Cystine/glutamate transporter ;
Amino acid transport system xc- ;
Calcium channel blocker resistance protein CCBR1 ;
Solute carrier family 7 member 11 ;
xCT ;
Amino acid transport system xc- ;
Calcium channel blocker resistance protein CCBR1 ;
Solute carrier family 7 member 11 ;
xCT ;
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Background:
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
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Function:
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.
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Cellular Localization:
Membrane ; Multi-pass membrane protein .
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Signaling Pathway
Reference Citation({{totalcount}})
Catalog: YT8130
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$160.00
In stock
0
Add to cart
Collected
Collect
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