Catalog: YT7904
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Main Information
Target
BDNF
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
MW
27kD (Calculated)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:1000-2000; ELISA 1:5000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat BDNF
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Calculated)
27kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from human BDNF
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Specificity:
This antibody detects endogenous levels of Human,Mouse,Rat BDNF
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Gene Name:
BDNF
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Protein Name:
BDNF(Brain Derived Neurotrophic Factor)
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Other Name:
Brain-derived neurotrophic factor ;
BDNF ;
Abrineurin ;
BDNF ;
Abrineurin ;
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Background:
This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]
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Function:
Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678).
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability
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Cellular Localization:
Secreted .; [BDNF precursor form]: Secreted . A proportion of BDNF is secreted as immature precursor (proBDNF). .
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Research Areas:
>>MAPK signaling pathway ;
>>Ras signaling pathway ;
>>cAMP signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Neurotrophin signaling pathway ;
>>Huntington disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Cocaine addiction ;
>>Alcoholism
>>Ras signaling pathway ;
>>cAMP signaling pathway ;
>>PI3K-Akt signaling pathway ;
>>Neurotrophin signaling pathway ;
>>Huntington disease ;
>>Pathways of neurodegeneration - multiple diseases ;
>>Cocaine addiction ;
>>Alcoholism
show all
Reference Citation({{totalcount}})
Catalog: YT7904
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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