Synthesized peptide derived from human LWS. at AA range: 380-420

This antibody detects endogenous levels of LWS

RXRG NR2B3

LWS

Retinoic acid receptor RXR-gamma ;
Nuclear receptor subfamily 2 group B member 3 ;
Retinoid X receptor gamma ;

retinoid X receptor gamma(RXRG) Homo sapiens This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010],

Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,Domain:Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.,Function:Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA).,similarity:Belongs to the nuclear hormone receptor family. NR2 subfamily.,similarity:Contains 1 nuclear receptor DNA-binding domain.,

Nucleus . Cytoplasm .

Expressed in aortic endothelial cells (at protein level).

>>PPAR signaling pathway ;
>>Th17 cell differentiation ;
>>Thyroid hormone signaling pathway ;
>>Adipocytokine signaling pathway ;
>>Parathyroid hormone synthesis, secretion and action ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Chemical carcinogenesis - receptor activation ;
>>Thyroid cancer ;
>>Small cell lung cancer ;
>>Non-small cell lung cancer ;
>>Gastric cancer ;
>>Lipid and atherosclerosis