Catalog: YT5775
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
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Collected
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Main Information
Target
TRAF1
Host Species
Rabbit
Reactivity
Human, Mouse
Applications
WB, ELISA
MW
46kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-2000; ELISA 1:10000-20000
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
TRAF1 Polyclonal Antibody detects endogenous levels of TRAF1
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
46kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Antigen&Target Information
Immunogen:
Synthesized peptide derived from TRAF1 at AA range: 191-240
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Specificity:
TRAF1 Polyclonal Antibody detects endogenous levels of TRAF1
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Gene Name:
TRAF1
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Protein Name:
TRAF1
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Other Name:
TNF receptor-associated factor 1 ;
Epstein-Barr virus-induced protein 6 ;
Epstein-Barr virus-induced protein 6 ;
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Background:
TNF receptor associated factor 1(TRAF1) Homo sapiens The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have
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Function:
Domain:The coiled coil domain mediates homo- and hetero-oligomerization.,Domain:The MATH/TRAF domain binds to receptor cytoplasmic domains.,Function:Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and JNK and is involved in apoptosis. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2.,similarity:Contains 1 MATH domain.,subunit:Homotrimer (Probable). Heteromer with TRAF2 and associates with TNFRSF1B/TNFR2 through TRAF2. Associates with TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF9/CD137, TNFRSF11A/RANK, TNFRSF18/AITR, TNFRSF17/BCMA, TNFRSF19/TROY, TNFRSF19L/RELT, XEDAR, EDAR, Epstein-Barr virus BNFL1/LMP-1, TANK/ITRAF, TRAIP and RIPK2. Interacts with BIRC2 and BIRC3 N-terminus. Interacts wtih NFATC2IP and with HIVEP3.,
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Cellular Localization:
cytoplasm,cytosol,
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Tissue Expression:
Lymphoma,Skin,Spleen,Stomach,
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Research Areas:
>>NF-kappa B signaling pathway ;
>>Apoptosis ;
>>TNF signaling pathway ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Viral carcinogenesis ;
>>Small cell lung cancer
>>Apoptosis ;
>>TNF signaling pathway ;
>>Pathways in cancer ;
>>Transcriptional misregulation in cancer ;
>>Viral carcinogenesis ;
>>Small cell lung cancer
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Signaling Pathway
Cellular Processes >> Cell growth and death >> Apoptosis
Human Diseases >> Cancer: overview >> Pathways in cancer
Human Diseases >> Cancer: overview >> Transcriptional misregulation in cancer
Human Diseases >> Cancer: specific types >> Small cell lung cancer
Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway
Environmental Information Processing >> Signal transduction >> TNF signaling pathway
Reference Citation({{totalcount}})
Catalog: YT5775
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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