The antiserum was produced against synthesized peptide derived from human ATP6V1H. AA range:341-390

V-ATPase H Polyclonal Antibody detects endogenous levels of V-ATPase H protein.

ATP6V1H

V-type proton ATPase subunit H

ATP6V1H ;
CGI-11 ;
V-type proton ATPase subunit H ;
V-ATPase subunit H ;
Nef-binding protein 1 ;
NBP1 ;
Protein VMA13 homolog ;
V-ATPase 50/57 kDa subunits ;
Vacuolar proton pump subunit H ;
Vacuolar proton pump subunit SFD

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular organelles. V-ATPase-dependent organelle acidification is necessary for multiple processes including protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. The encoded protein is the regulatory H subunit of the V1 domain of V-ATPase, which is required for catalysis of ATP but not the assembly of V-ATPase. Decreased expression of this gene may play a role in the development of type 2 diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012],

Function:Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes.,similarity:Belongs to the V-ATPase H subunit family.,subunit:V-ATPase is an heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d). Interacts with HIV-1 Nef protein and AP2M1.,tissue specificity:Widely expressed.,

Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Peripheral membrane protein .

>>Oxidative phosphorylation ;
>>Metabolic pathways ;
>>Lysosome ;
>>Phagosome ;
>>mTOR signaling pathway ;
>>Synaptic vesicle cycle ;
>>Vibrio cholerae infection ;
>>Epithelial cell signaling in Helicobacter pylori infection ;
>>Tuberculosis ;
>>Human papillomavirus infection ;
>>Rheumatoid arthritis