Catalog: YT4710
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
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Main Information
Target
Tryptophan Hydroxylase
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
51kD (Observed)
Conjugate/Modification
Unmodified
Detailed Information
Recommended Dilution Ratio
WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Specificity
TPH1 Polyclonal Antibody detects endogenous levels of TPH1 protein.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
1 mg/ml
MW(Observed)
51kD
Modification
Unmodified
Clonality
Polyclonal
Isotype
IgG
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Primary Antibodies
TPH1 Rabbit pAb
YT4710
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Primary Antibodies
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YT4709
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Primary Antibodies
TPH1 (Phospho Ser260) Rabbit pAb
YP0748
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Primary Antibodies
TPH1 (Phospho Ser58) Rabbit pAb
YP0747
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ELISA Kits
Total Tryptophan Hydroxylase Cell-Based Colorimetric ELISA Kit
KA4311C
More→
ELISA Kits
Tryptophan Hydroxylase (Phospho Ser260) Cell-Based Colorimetric ELISA Kit
KA1480C
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ELISA Kits
Tryptophan Hydroxylase (Phospho Ser58) Cell-Based Colorimetric ELISA Kit
KA1479C
More→
Antigen&Target Information
Immunogen:
The antiserum was produced against synthesized peptide derived from human Tryptophan Hydroxylase. AA range:231-280
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Specificity:
TPH1 Polyclonal Antibody detects endogenous levels of TPH1 protein.
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Gene Name:
TPH1
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Protein Name:
Tryptophan 5-hydroxylase 1
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Other Name:
TPH1 ;
TPH ;
TPRH ;
TRPH ;
Tryptophan 5-hydroxylase 1 ;
Tryptophan 5-monooxygenase 1
TPH ;
TPRH ;
TRPH ;
Tryptophan 5-hydroxylase 1 ;
Tryptophan 5-monooxygenase 1
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Database Link:
Background:
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009],
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Function:
Catalytic activity:L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.,cofactor:Fe(2+) ion.,pathway:Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2.,similarity:Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.,similarity:Contains 1 ACT domain.,subunit:Multimer of identical subunits.,tissue specificity:Isoform 2 seems to be less widely expressed than isoform 1.,
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Cellular Localization:
cytosol,neuron projection,
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Tissue Expression:
[Isoform 2]: Seems to be less widely expressed than isoform 1.
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Research Areas:
>>Tryptophan metabolism ;
>>Folate biosynthesis ;
>>Metabolic pathways ;
>>Serotonergic synapse
>>Folate biosynthesis ;
>>Metabolic pathways ;
>>Serotonergic synapse
show all
Reference Citation({{totalcount}})
Catalog: YT4710
Size
Price
Status
Qty.
200μL
$450.00
In stock
0
100μL
$280.00
In stock
0
40μL
$150.00
In stock
0
Add to cart
Collected
Collect
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